How Methylene Blue can do wonders in Different Aspects of Health


Methylene Blue Staining

Methylene Blue (Methylthioninium Chloride) is a blue dye and a bioactive substance that was first used in the treatment of Malaria in 1891. Recently it has got much attention due potential benefits of methylene blue as nootropic and anti-aging substance. It is effective against neurodegeneration, treats depression, reverses skin aging, enhances memory and cognition, is shown to be a potent anticancer drug, and is also used as a dye ¹ ²


  1. Methylene blue in Covid-19
    COVID-19 might be treated using methylene blue. Methylene Blue Inhibits the SARS-CoV-2 Spike–ACE2 Protein-Protein Interaction, which works as an antiviral and prohibits its viral effect. Moreover, methylene blue is a cheap and widely available dye-based medication, making it easy for underdeveloped countries to use it for prevention and treatment against Covid-19.⁴ ⁵
  2. Methylene blue as a nootropic
    Neurodegenerative diseases such as Alzheimer’s, Dementia, Parkinson’s, and Huntington’s diseases can be treated using methylene blue. It is a nootropic that can quickly cross the blood-brain barrier & decrease the production of proteins, causing memory consolidation resulting in increased brain life, improved memory, enhanced mood, and longevity.³ ⁶ ⁷
    Methylene blue prevents the brain from damage caused by cytotoxic tumors by encouraging cellular oxygen consumption and decreasing anaerobic glycolysis. Memory can be improved by a single small dose of methylene blue for some time. It increases response rate and correctness by 7% during memory retrieval.⁶
  3. Enhance mitochondrial efficiency and energy production
    The efficacy of mitochondria can be improved using methylene blue. It performs as an electron donor for complex I-IV of the mitochondria, increasing adenosine triphosphate (ATP) production. ATP work as an energy currency of the cell; therefore, increased ATP production boosts sirtuin activation, which keeps your cells younger, resulting in improved physical and mental performance. Similarly, a decrease in ATP production can cause a decline in your physical and mental health.²
  4. Methylene blue is a powerful antioxidant for skin
    Production of skin cells increases and the number of damaged molecules decreases with methylene blue. Research at the University of Maryland proved that methylene blue is an effective antioxidant in connective tissue cells. They experimented on the middle-aged human group and found that this chemical lowered the rate of cell death, increased cell division, and reduced the number of damaged molecules. Further, components in sunscreen can be replaced by methylene blue to prevent the skin from the environment.² ⁶
  5. During Surgery or Imaging
    Methylene blue can be used as a visual aid for identifying tissue, polyps, lesions, nerve fibers, and more. Methylene blue can also be used for bacteriologic stain, cellular stain, as an indicator dye, and for surgical and medical marking. Membrane damage can be identified using staining with methylene blue.⁸
  6. Methylene blue in cancer treatment
    Cancer can be treated using methylene blue as it effectively kills cells that cause cancer. Photodynamic therapy (PDT) for cancer treatment uses methylene blue and induces massive cancer cells death. An experiment was done against breast cancer, and the results were very fruitful.⁹
  7. Anti-microbial properties of methylene blue
    Methylene blue helps stain and inactivate certain microbes when methylene blue is combined with the particular spectrum of light (UV, primarily) and might prove anti-infective against some other infections, bacteria, and viruses, including coronavirus. Urinary tract infections can also be treated using methylene blue.¹⁰ ¹¹
  8. Treatment of Depression
    It inhibits monoamine oxidase (MAO), which causes monoamine neurotransmitter breakdown resulting in depression. Thus, preventing monoamine neurotransmitters can help reduce depression. Methylene blue could not be combined with any other antidepressants.² ³
  9. Methylene blue in Blood pressure
    Blood Pressure could be quickly restored using methylene blue, a nitric oxide synthase inhibitor, and guanylate cyclase. It might be very helpful during septic shock, where immediate blood pressure recovery is essential. However, large doses might result in high blood pressure.¹²
  10. Benefits of methylene blue in the aquarium
    Fish tank cleaner contains methylene blue as it is an anti-fungal agent and prevents fungal growth in fish tanks. Methylene blue is considered aquarium-safe, anti-parasitic and anti-fungal, which saves fish eggs from being destroyed.¹³


Methylene blue has many health benefits and has been used for years in medical research and treatments. Recent aspects of methylene blue as a nootropic and anti-aging drug is supported scientifically.

How to get Methylene Blue

The simplest option is to order it from our Amazon store —
We guarantee that we sell the purest grade of Methylene Blue which is the USP grade.

We also send the COA(Certificate of Analysis) with all the powder orders — this ensures that our quality is up to the mark verified by a third party.


1. Müller O, Lu G, Jahn A, Mockenhaupt FP. How worthwhile is methylene blue as a treatment of malaria? 2019;17(7):471–473. doi:10.1080/14787210.2019.1634545

2. Tucker D, Lu Y, Zhang Q. From Mitochondrial Function to Neuroprotection — an Emerging Role for Methylene Blue. Molecular Neurobiology 2017 55:6. 2017;55(6):5137–5153.


3. Pushparajah Mak RS, Liebelt EL. Methylene Blue: An Antidote for Methemoglobinemia and Beyond. Pediatric emergency care. 2021;37(9):474–477. doi:10.1097/PEC.0000000000002526

4. Scigliano G, Scigliano GA. Methylene blue in covid-19. Medical Hypotheses. 2021;146:110455. doi:10.1016/J.MEHY.2020.110455

5. Ghahestani SM, Shahab E, Karimi S, Madani MH. Methylene blue may have a role in the treatment of COVID-19. Medical Hypotheses. 2020;144:110163. doi:10.1016/J.MEHY.2020.110163

6. Mei Xiong Z, O’Donovan M, Sun L, Young Choi J, Ren M, Cao K. Anti-Aging Potentials of Methylene Blue for Human Skin Longevity. Scientific Reports 2017 7:1. 2017;7(1):1–12. doi:10.1038/s41598–017–02419–3

7. Howland MA. Methylene blue. History of Modern Clinical Toxicology. Published online January 1, 2022:231–241. doi:10.1016/B978–0–12–822218–8.00052–1

8. van Manen L, Handgraaf HJM, Diana M, et al. A practical guide for the use of indocyanine green and methylene blue in fluorescence-guided abdominal surgery. Journal of Surgical Oncology. 2018;118(2):283–300. doi:10.1002/JSO.25105

9. Zhai Y, Ran W, Su J, et al. Traceable Bioinspired Nanoparticle for the Treatment of Metastatic Breast Cancer via NIR-Trigged Intracellular Delivery of Methylene Blue and Cisplatin. Advanced Materials. 2018;30(34):1802378. doi:10.1002/ADMA.201802378

10. Cabral F v., Sabino CP, Dimmer JA, Sauter IP, Cortez MJ, Ribeiro MS. Preclinical Investigation of Methylene Blue-mediated Antimicrobial Photodynamic Therapy on Leishmania Parasites Using Real-Time Bioluminescence. Photochemistry and Photobiology. 2020;96(3):604–610. doi:10.1111/PHP.13188

11. Gendrot M, Andreani J, Duflot I, et al. Methylene blue inhibits replication of SARS-CoV-2 in vitro. International Journal of Antimicrobial Agents. 2020;56(6):106202. doi:10.1016/J.IJANTIMICAG.2020.106202

12. McCartney SL, Duce L, Ghadimi K. Intraoperative vasoplegia: methylene blue to the rescue! Current Opinion in Anaesthesiology. 2018;31(1):43–49. doi:10.1097/ACO.0000000000000548

13. Sharma P, Olufemi AF, Qanungo K. Development of green geo-adsorbent pellets from low fire clay for possible use in methylene blue removal in aquaculture. Materials Today: Proceedings. 2022;49:1556–1565. doi:10.1016/J.MATPR.2021.07.343

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